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Proteases rapidly degrade many peptides, exhibit poor oral bioavailability due to enzymatic breakdown in the digestive tract, and suffer from short systemic half-lives, reducing their clinical efficacy

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AA is transported into the brain and neurons primarily by the sodium-dependent vitamin C transporter 2 (SVCT2) 38

But, this cannot be the whole story as there are actually multiple EpRE elements in the promoters and not all of them are involved in regulating transcription (Dickinson et al., 2004)